𝔖 Bobbio Scriptorium
✦   LIBER   ✦

DISSECTING THE MOLECULAR MECHANISMS OF TCR ζ CHAIN DOWNREGULATION AND T Cell SIGNALING ABNORMALITIES IN HUMAN SYSTEMIC LUPUS ERYTHEMATOSUS

✍ Scribed by NAMBIAR, MADHUSOODANA P.; JUANG, YUANG-TAUNG; KRISHNAN, SANDEEP; TSOKOS, GEORGE C.


Book ID
118015142
Publisher
Informa plc
Year
2004
Tongue
English
Weight
645 KB
Volume
23
Category
Article
ISSN
0883-0185

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Effect of trichostatin A on human T cell
✍ Madhusoodana P. Nambiar; Vishal G. Warke; Carolyn U. Fisher; George C. Tsokos 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB

## Abstract Trichostatin A (TSA) is a potent reversible inhibitor of histone deacetylase, and it has been reported to have variable effects on the expression of a number of genes. In this report, we show that TSA suppresses the expression of the T cell receptor ζ chain gene, whereas, it upregulates

T cell signaling abnormalities in system
✍ Madhusoodana P. Nambiar; Edith J. Enyedy; Vishal G. Warke; Sandeep Krishnan; Gre 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB 👁 2 views

## Objective. T cells from patients with systemic lupus erythematosus (SLE ) display antigen receptormediated signaling aberrations associated with defective T cell receptor (TCR) chain protein and messenger RNA (mRNA) expression. This study was undertaken to explore the possibility that coding-re