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Abnormal expression of various molecular forms and distribution of T cell receptor ζ chain in patients with systemic lupus erythematosus

✍ Scribed by Madhusoodana P. Nambiar; Edith J. Enyedy; Carolyn U. Fisher; Sandeep Krishnan; Vishal G. Warke; William R. Gilliland; Robert J. Oglesby; George C. Tsokos

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
630 KB
Volume
46
Category
Article
ISSN
0004-3591

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## Objective. T cells from patients with systemic lupus erythematosus (SLE ) display antigen receptormediated signaling aberrations associated with defective T cell receptor (TCR) chain protein and messenger RNA (mRNA) expression. This study was undertaken to explore the possibility that coding-re

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## Abstract Trichostatin A (TSA) is a potent reversible inhibitor of histone deacetylase, and it has been reported to have variable effects on the expression of a number of genes. In this report, we show that TSA suppresses the expression of the T cell receptor ζ chain gene, whereas, it upregulates