The effect of food on the pharmacokinetics of the antiepileptic oxcarbazepine (OXC) was investigated in healthy volunteers. Six healthy male volunteers were treated with single peroral doses of 600 mg of oxcarbazepine (Trileptal@) after overnight fasting or a fat-and protein-rich breakfast. Mean ( k
Disposition of the antiepileptic oxcarbazepine and its metabolites in healthy volunteers
โ Scribed by M. Theisohn; G. Heimann
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 778 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0031-6970
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CS-670, a novel nonsteroidal anti-inflammatory drug, is a racemic prodrug. Plasma concentrations and urinary excretion of CS-670 and its metabolites were determined in experimental subjects after oral administration at a single 120 mg dose. CS-670 and four metabolites, the saturated ketone (M-A), un