We have studied the effects of intravenous nicorandil, a mixed arterial and venous vasodilator, in 48 healthy volunteers. Nicorandil (20, 28, 39, 54, 74, 103, 144, or 200 micrograms.kg-1) or placebo were given over 5 min to subjects supine (16 subjects, 2 doses) or sitting (32 subjects, 1 dose) in a
The pharmacokinetics and haemodynamics of BTS 49465 and its major metabolite in healthy volunteers
โ Scribed by R. D. Wynne; E. L. Crampton; I. D. Hind
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 558 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
We have studied the pharmacokinetics and haemodynamic effects of nicorandil after a 12-h infusion. Nicorandil is a mixed vasodilator combining the actions of a nitrate and a potassium channel opener. Nicorandil was infused for 12 h in 21 healthy volunteers at rates of 0.05, 0.10, and 0.20 microgram.
The effect of food on the pharmacokinetics of the antiepileptic oxcarbazepine (OXC) was investigated in healthy volunteers. Six healthy male volunteers were treated with single peroral doses of 600 mg of oxcarbazepine (Trileptal@) after overnight fasting or a fat-and protein-rich breakfast. Mean ( k