Disposition and removal of metronidazole in patients undergoing haemodialysis
โ Scribed by A. Somogyi; C. Kong; J. Sabto; F. W. Gurr; W. J. Spicer; A. J. McLean
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 649 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
A pharmacokinetic study of metronidazole disposition was performed in 10 patients with severe liver disease, the majority of whom also had impaired renal function. Following a single intravenous dose, systemic clearance of metronidazole was decreased by 66% in patients compared with healthy
The effect of haemodialysis on the pharmacokinetics of oral famotidine has been studied in five elderly anuric patients. Famotidine 20 mg was administered in a cross-over design to patients on and not on haemodialysis. The elimination rate constant of haemodialysis (k) was 4.6-fold larger than the s