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Removal of famotidine by haemodialysis in elderly anuric patients

โœ Scribed by N. Inotsume; M. Nishimura; M. Nakano; S. Fujiyama; K. Sagara; T. Sato; K. Matsushita; Y. Imai; H. Matsui

Publisher
Springer
Year
1990
Tongue
English
Weight
177 KB
Volume
38
Category
Article
ISSN
0031-6970

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โœฆ Synopsis

The effect of haemodialysis on the pharmacokinetics of oral famotidine has been studied in five elderly anuric patients. Famotidine 20 mg was administered in a cross-over design to patients on and not on haemodialysis. The elimination rate constant of haemodialysis (k) was 4.6-fold larger than the systemic elimination rate constant (ke). Although the mean maximum serum concentration of famotidine during haemodialysis (141.5 ng.ml-1) was not significantly lower than that without haemodialysis (195.6 ng.ml-1), the AUC up to 5 h during haemodialysis was significantly decreased to 58.1% of the value without it. The data suggest that famotidine is dialysable by haemodialysis.

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