Displacement of lidocaine from serumα1-acid glycoprotein binding sites by basic drugs
✍ Scribed by D. L. Goolkasian; R. L. Slaughter; D. J. Edwards; D. Lalka
- Book ID
- 105045627
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 481 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0031-6970
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## Abstract Interactions between α~1~‐acid glycoprotein (AGP) and 52 basic drugs were quantified by means of highperformance liquid chromatography (HPLC). The HPLC retention parameters were related quantitatively to the hydrophobicity and molecular modelling parameters, giving rise to the predictio
The function of sialic acid groups at the terminal of sugar chains of human ␣ 1 -acid glycoprotein (AGP) was investigated with respect to chiral discrimination between optical isomers of basic drugs, using high-performance capillary electrophoresis/frontal analysis (HPCE/FA), a novel analytical meth