𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Characterization of a common binding site for basic drugs on human α2-acid glycoprotein (orosomucoid)

✍ Scribed by Walter E. Müller; Angelika E. Stillbauer


Book ID
112353460
Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
379 KB
Volume
322
Category
Article
ISSN
0028-1298

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Binding of several phenothiazine neurole
✍ Safaa El-Gamal; Uwe Wollert; Walter E. Müller 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 388 KB

The interaction of several phenothiazine neuroleptics with alpha 1-acid glycoprotein was investigated using circular dichroism and equilibrium dialysis techniques. For chlorpromazine only, one high-affinity binding site of the protein was found. The binding of the drug to this single site generated

Binding site for basic drugs on α1-acid
✍ Roman Kaliszan; Antoni Nasal; Maciej Turowski 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB 👁 1 views

## Abstract Interactions between α~1~‐acid glycoprotein (AGP) and 52 basic drugs were quantified by means of highperformance liquid chromatography (HPLC). The HPLC retention parameters were related quantitatively to the hydrophobicity and molecular modelling parameters, giving rise to the predictio

Effect of sialic acid residues of human
✍ Hiromitsu Shiono; Akimasa Shibukawa; Yukihiro Kuroda; Terumichi Nakagawa 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 1 views

The function of sialic acid groups at the terminal of sugar chains of human ␣ 1 -acid glycoprotein (AGP) was investigated with respect to chiral discrimination between optical isomers of basic drugs, using high-performance capillary electrophoresis/frontal analysis (HPCE/FA), a novel analytical meth

A site-directed mutagenesis study of dru
✍ Koji Nishi; Megumi Ueno; Yuka Murakami; Naoko Fukunaga; Teruo Akuta; Daisuke Kad 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB

Human alpha(1)-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1\*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid resid