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Binding of several phenothiazine neuroleoptics to a common binding site of α1-acid glycoprotein, orosomucoid

✍ Scribed by Safaa El-Gamal; Uwe Wollert; Walter E. Müller

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
388 KB
Volume
72
Category
Article
ISSN
0022-3549

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✦ Synopsis

The interaction of several phenothiazine neuroleptics with alpha 1-acid glycoprotein was investigated using circular dichroism and equilibrium dialysis techniques. For chlorpromazine only, one high-affinity binding site of the protein was found. The binding of the drug to this single site generated typical polyphasic extrinsic Cotton effects. Since several other phenothiazine neuroleptics gave qualitatively comparable extrinsic Cotton effects in the presence of alpha 1-acid glycoprotein and potently inhibited the binding of chlorpromazine to the single site, it was concluded that all phenothiazine derivatives investigated bound preferentially to only one common binding site of the alpha 1-acid glycoprotein molecule.

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