Binding of disopyramide to α1-acid glycoprotein in plasma measured by competitive equilibrium dialysis

✍ Scribed by R. L. G. Norris; P. J. Ravenscroft; J. T. Ahokas; M. Henry

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 379 KB
• Volume: 73
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600730630

✦ Synopsis

A modification of equilibrium dialysis in which a]-acid glycoprotein and plasma compete directly for disopyrarnide has been used in conjunction with binding curves to measure the extent of the al-acid glycoprotein-disopyramide interaction. At concentrations in the therapeutic range, 80-90% of disopyramide was bound to al-acid glycoprotein for plasma from each of six healthy adults. Also, equilibrium dialysis data are presented, indicating that pH does not influence the binding of disopyramide within the therapeutic range.

Key phrases 0 Disopyramide-binding to a!-acid glycoprotein, competitive equilibrium dialysis 0 Equilibrium dialysis, competitive-binding of disopyramide to a]-acid glycoprotein 0 q -A c i d glycoprotein-binding ofdisopyramide, competitive equilibrium dialysis ' PCS 11; Amersham Aust. k y . Ltd.. Surrey Hills. NSW, Australia.