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Discrepancies between precursor uptake and DNA synthesis in mammalian cells

✍ Scribed by L. A. Smets

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
269 KB
Volume
74
Category
Article
ISSN
0021-9541

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✦ Synopsis

The incorporation of tritiated thymidine and deoxycytidine into DNA of x-irradiated mammalian cells was studied. Both inhibition and stimulation were found due to pool changes rather than to effects on DNA synthesis, indicating that precursor uptake can be a misleading method to measure DNA synthesis rate.

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