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Control of DNA synthesis in polyploid mammalian cells

✍ Scribed by Jennifer A. Marshall Graves; Julie McMillan

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
551 KB
Volume
121
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

To test the hypothesis that the duration of DNA synthesis is an inverse function of nuclear size or DNA content, the S phase was calculated from PLM analysis for pseudodiploid, tetraploid, and octaploid lines of Chinese hamster cells growing as a monolayer or in suspension. S phase times were found not to be significantly different between polyploid lines and the diploid lines from which they were derived, regardless of the conformation of the nucleus. There is no evidence, therefore, that would implicate t h e nuclear membrane, or nuclear surface aredvolume relationships, in the control of DNA synthesis.

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