𝔖 Bobbio Scriptorium
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Discovery of the First Antibacterial Small Molecule Inhibitors of MurB.

✍ Scribed by Joanne J. Bronson; Kenneth L. DenBleyker; Paul J. Falk; Robert A. Mate; Hsu-Tso Ho; Michael J. Pucci; Lawrence B. Snyder

Publisher
John Wiley and Sons
Year
2003
Weight
121 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we