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Discovery of a Small-Molecule Inhibitor of the KIX–KID Interaction

✍ Scribed by Bingbing X. Li; Xiangshu Xiao


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
298 KB
Volume
10
Category
Article
ISSN
1439-4227

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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we