The First Small-Molecule Inhibitor of 14-3-3s: Modulating the Master Regulator

Changes in Osteoblast, Chondrocyte, and

Changes in Osteoblast, Chondrocyte, and Adipocyte Lineages Mediate the Bone Anabolic Actions of PTH and Small Molecule GSK-3 Inhibitor

✍ Nalini H. Kulkarni; Tao Wei; Amar Kumar; Ernst R. Dow; Trent R. Stewart; Jianyon 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB

## Abstract Parathyroid hormone (PTH) and glycogen synthase kinase‐3 (GSK‐3) inhibitor 603281‐31‐8, administered once daily increased bone formation in vivo. We investigated the molecular mechanisms of the anabolic responses of PTH and 603281‐31‐8 in rat osteopenia model. Female 6‐month‐old rats we

First Synthesis of the Cytotoxic and Ant

First Synthesis of the Cytotoxic and Antifungal C14-Amine (2S,3E,5Z)-2-Amino-3,5,13-tetradecatriene Isolated from the New Zealand AscidianPseudodistoma novaezelandiae

✍ Enders, Dieter ;Finkam, Michael 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 479 KB

## Abstract The synthesis of (2__S__,3__E__,5__Z__)‐2‐amino‐3,5,13‐tetradecatriene [(__S__‐1)] with high enantiomeric purity in excellent overall yield is described. In the crucial step the stereogenic center was generated by nucleophilic addition of __tert__‐butyl carbamate to a planar‐chiral tetr

ChemInform Abstract: Discovery of the Fi

ChemInform Abstract: Discovery of the First Potent and Selective Small Molecule Opioid Receptor-Like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-4-piperidyl] -3-ethyl-1,3-diyhdro-2H-benzimidazol-2-one (J-113397).

✍ Hiroshi Kawamoto; Satoshi Ozaki; Yoshiki Itoh; Mitsuru Miyaji; Sachie Arai; Hiro 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

ChemInform Abstract: First Asymmetric Sy

ChemInform Abstract: First Asymmetric Synthesis of the Kelatorphan-Like Enkephalinase Inhibitor (1S,2R,2′S)-2- [2′-(N-Hydroxycarbamoylmethyl)-3′-phenylpropionylamino] cyclohexane-1-carboxylic Acid.

✍ S. G. DAVIES; D. J. DIXON 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 40 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Inhibition of Flt3-activating mutations

Inhibition of Flt3-activating mutations does not prevent constitutive activation of ERK/Akt/STAT pathways in some AML cells: a possible cause for the limited effectiveness of monotherapy with small-molecule inhibitors

✍ Emilio Siendones; Nuria Barbarroja; Luis Arístides Torres; Paula Buendía; Franci 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 1 views

## Abstract The Flt3 receptor tyrosine kinase is a critical mediator in the pathogenesis of acute myeloid leukaemia (AML). Flt3‐activating mutations have been associated with poor prognosis and decreased overall survival of AML patients, thus Flt3 constitutes an ideal target for drug treatment of s

ChemInform Abstract: First Stereoselecti

ChemInform Abstract: First Stereoselective Cyclization in the Cembrane Series: X-Ray Structure of (+)-(4R,8R,11S,12E,14S,16R) -11-Isopropyl-4,8,14-trimethyl-14-morpholin-4-yl-3-oxa-2-azatricyclo [6.6.2.04,16]hexadeca-1,12-diene.

✍ Alexander M. Agafontsev; Tatyana V. Rybalova; Yurii V. Gatilov; Alexey V. Tkache 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v