✦ LIBER ✦
First Synthesis of the Cytotoxic and Antifungal C14-Amine (2S,3E,5Z)-2-Amino-3,5,13-tetradecatriene Isolated from the New Zealand AscidianPseudodistoma novaezelandiae
✍ Scribed by Enders, Dieter ;Finkam, Michael
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 479 KB
- Volume
- 1993
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The synthesis of (2__S__,3__E__,5__Z__)‐2‐amino‐3,5,13‐tetradecatriene [(S‐1)] with high enantiomeric purity in excellent overall yield is described. In the crucial step the stereogenic center was generated by nucleophilic addition of tert‐butyl carbamate to a planar‐chiral tetracarbonyliron(1 +) complex.