## Background: We developed a series of dendritic cell autoimmune modulators (DCAMs) based on small molecule Flt3 receptor tyrosine kinase inhibitors (TKIs) for the inhibition of intestinal inflammation and oral delivery. Methods: DCAMs were administered orally during and after induction of dextr
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis
β Scribed by Harris, Philip A.; Bandyopadhyay, Deepak; Berger, Scott B.; Campobasso, Nino; Capriotti, Carol A.; Cox, Julie A.; Dare, Lauren; Finger, Joshua N.; Hoffman, Sandra J.; Kahler, Kirsten M.; Lehr, Ruth; Lich, John D.; Nagilla, Rakesh; Nolte, Robert T.; Ouellette, Michael T.; Pao, Christina S.; Schaeffer, Michelle C.; Smallwood, Angela; Sun, Helen H.; Swift, Barbara A.; Totoritis, Rachel D.; Ward, Paris; Marquis, Robert W.; Bertin, John; Gough, Peter J.
- Book ID
- 126000603
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 897 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1948-5875
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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for downβregulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we