𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Discovery of DF-461, a Potent Squalene Synthase Inhibitor

✍ Scribed by Ichikawa, Masanori; Ohtsuka, Masami; Ohki, Hitoshi; Ota, Masahiro; Haginoya, Noriyasu; Itoh, Masao; Shibata, Yoshihiro; Sugita, Kazuyuki; Ishigai, Yutaka; Terayama, Koji; Kanda, Akira; Usui, Hiroyuki


Book ID
121009823
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
613 KB
Volume
4
Category
Article
ISSN
1948-5875

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


The synthesis of C3-methyl, C3-decarboxy
✍ C.H. Kuo; S.P. Plevyak; T. Biftu; W.H. Parsons; G.D. Berger πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 French βš– 258 KB

The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11