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α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase

✍ Scribed by Magnin, David R.; Biller, Scott A.; Chen, Ying; Dickson,, John K.; Fryszman, Olga M.; Lawrence, R. Michael; Logan, Janette V. H.; Sieber-McMaster, Ellen S.; Sulsky, Richard B.; Traeger, Sarah C.; Hsieh, Dolly C.; Lan, Shih-Jung; Rinehart, J. Kent; Harrity, Thomas W.; Jolibois, Kern G.; Kunselman, Lori K.; Rich, Lois C.; Slusarchyk, Dorothy A.; Ciosek, Carl P.

Book ID: 127303224
Publisher: American Chemical Society
Year: 1996
Tongue: English
Weight: 145 KB
Volume: 39
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9507340

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The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11