Potent HIV protease inhibitors containin
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L. Rocheblave; G. Priem; C. De Michelis; J.L. Kraus
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Article
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1999
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Elsevier Science
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French
โ 187 KB
Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both in vitro activity on MT4 infected c~lls and H