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Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere

โœ Scribed by Getman, Daniel P.; DeCrescenzo, Gary A.; Heintz, Robert M.; Reed, Kathryn L.; Talley, John J.; Bryant, Martin L.; Clare, Michael; Houseman, Kathryn A.; Marr, J. Joseph


Book ID
118221831
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
460 KB
Volume
36
Category
Article
ISSN
0022-2623

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Potent HIV protease inhibitors containin
โœ L. Rocheblave; G. Priem; C. De Michelis; J.L. Kraus ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 187 KB

Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both in vitro activity on MT4 infected c~lls and H