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Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase

✍ Scribed by Nencka, Radim; Votruba, Ivan; Hřebabecký, Hubert; Jansa, Petr; Tloušt'ová, Eva; Horská, Květa; Masojídková, Milena; Holý, Antonín

Book ID
111885173
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
258 KB
Volume
50
Category
Article
ISSN
0022-2623

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✍ Matthew R. Birck; Keith Clinch; Graeme J. Gainsford; Vern L. Schramm; Peter C. T 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 German ⚖ 269 KB

## Abstract magnified image By attaching (methyl)‐ or (difluoromethyl)‐phosphonate groups to the 1‐positions of ethene, cyclopentene or benzene, and attaching 1‐(methyl)‐5‐chlorouracil or 1‐(methyl)thymine groups to the corresponding 2‐positions, compounds **1**–**5** were prepared as potential in