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Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors

✍ Scribed by Udo Bauer; Fabrizio Giordanetto; Martin Bauer; Gavin O’Mahony; Kjell E. Johansson; Wolfgang Knecht; Judith Hartleib-Geschwindner; Eva Töppner Carlsson; Cristofer Enroth


Book ID
113496608
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
586 KB
Volume
22
Category
Article
ISSN
0960-894X

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Discovery of 1,6-Naphthyridines as a Novel Class of Potent and Selective Human Cytomegalovirus Inhibitors. -A series of 20 1,6-naphthyridines, e.g. (I), is synthesized by amidation of key intermediate (IV) and in case of its halogen analogue (V) by subsequent Stille coupling with stannanes, e.g. (V