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Discovery of 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as Potent MEK1 Inhibitors.

✍ Scribed by Chamakura V. N. S. Varaprasad; et al. et al.

Publisher: John Wiley and Sons
Year: 2006
Weight: 12 KB
Volume: 37
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200645131

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## Abstract magnified image A fast, efficient synthesis of 5‐substituted‐1,3,4‐thiadiazole‐2‐thiols was successfully developed, assessed using green chemistry matrices, and compounds were screened for their __in vitro__ nitrification inhibitory activity. The greener method was superior with higher