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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

✍ Scribed by Liu, Gang; Szczepankiewicz, Bruce G.; Pei, Zhonghua; Janowick, David A.; Xin, Zhili; Hajduk, Philip J.; Abad-Zapatero, Cele; Liang, Heng; Hutchins, Charles W.; Fesik, Stephen W.; Ballaron, Steve J.; Stashko, Mike A.; Lubben, Tom; Mika, Amanda K.; Zinker, Bradley A.; Trevillyan, James M.; Jirousek, Michael R.


Book ID
126986718
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
267 KB
Volume
46
Category
Article
ISSN
0022-2623

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A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.