Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
✍ Scribed by Liu, Gang; Szczepankiewicz, Bruce G.; Pei, Zhonghua; Janowick, David A.; Xin, Zhili; Hajduk, Philip J.; Abad-Zapatero, Cele; Liang, Heng; Hutchins, Charles W.; Fesik, Stephen W.; Ballaron, Steve J.; Stashko, Mike A.; Lubben, Tom; Mika, Amanda K.; Zinker, Bradley A.; Trevillyan, James M.; Jirousek, Michael R.
- Book ID
- 126986718
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 267 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2623
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract For Abstract see ChemInform Abstract in Full Text.
A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.