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Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors

✍ Scribed by Dai, Hou-ling; Gao, Li-xin; Yang, Ying; Li, Jing-ya; Cheng, Jia-gao; Li, Jia; Wen, Ren; Peng, Yan-qing; Zheng, Jian-bin


Book ID
122084162
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
645 KB
Volume
22
Category
Article
ISSN
0960-894X

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A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.