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Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors

โœ Scribed by Harris, Philip A.; Cheung, Mui; Hunter, Robert N.; Brown, Matthew L.; Veal, James M.; Nolte, Robert T.; Wang, Liping; Liu, Wendy; Crosby, Renae M.; Johnson, Jennifer H.; Epperly, Andrea H.; Kumar, Rakesh; Luttrell, Deirdre K.; Stafford, Jeffrey A.


Book ID
120353324
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
464 KB
Volume
48
Category
Article
ISSN
0022-2623

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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical