𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and chemical synthesis of [1,2,4]triazol[1,5-c]pyrimidin-5-yl amines, a novel class of VEGFR-2 kinase inhibitors

✍ Scribed by Alexander S. Kiselyov; Eugene L. Piatnitski Chekler; Natalia B. Chernisheva; Lev K. Salamandra; Victor V. Semenov

Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
316 KB
Volume
50
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of 1-(1H-Imidazol-2-yl)ethane-
Synthesis of 1-(1H-Imidazol-2-yl)ethane-1,2-diol Derivatives: A novel class of protein kinase C inhibitors
✍ Andreas N. Röhrle; Helmut Schmidhammer 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 German ⚖ 473 KB

Compounds 6-13 were prepared starting from 1-(triphenlymethy1)-protected 1H-imidazoles 14 and 15 in several steps. Lithiation with BuLi in T H F followed by reaction with (triphcny1methoxy)acetaldehyde (16) afforded 17 and 18, respectively. 0-Methylation of 17 and 18 gave diethers 19 and 20, respect

Synthesis of some novel pyrazolo[1,5-a]p
Synthesis of some novel pyrazolo[1,5-a]pyrimidine, 1,2,4-triazolo[1,5-a]pyrimidine, pyrido[2,3-d]pyrimidine, pyrazolo[5,1-c]-1,2,4-triazine and 1,2,4-triazolo[5,1-c]-1,2,4-triazine derivatives incorporating a thiazolo[3,2-a]benzimidazole moiety
✍ Hatem A. Abdel-Aziz; Nehal A. Hamdy; Issa M. I. Fakhr; Ahmad M. Farag 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 407 KB

## Abstract magnified image __E__‐3‐(__N,N__‐Dimethylamino)‐1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)prop‐2‐en‐1‐one (**2**) was synthesized by the reaction of 1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)ethanone (**1**) with dimethylformamide‐dimethylacetal. The reaction of **2** with