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Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: synthesis, biological evaluation and molecular docking

โœ Scribed by Xi, Liang; Zhang, Jian-Qiang; Liu, Zhi-Cheng; Zhang, Ji-Hong; Yan, Ju-Fang; Jin, Yi; Lin, Jun


Book ID
120445730
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
790 KB
Volume
11
Category
Article
ISSN
1477-0520

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Design, synthesis and biological evaluat
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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical