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Discovery and Development of Purine-Scaffold Hsp90 Inhibitors

✍ Scribed by Chiosis, Gabriela


Book ID
118057020
Publisher
Bentham Science Publishers
Year
2006
Tongue
English
Weight
165 KB
Volume
6
Category
Article
ISSN
1568-0266

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A facile and efficient synthesis of d6-l
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## Abstract PU‐H71 is a purine‐scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d~6~‐labeled PU‐H71 for use as an internal standard to accurately quantitate the drug in