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601 The Antimyeloma Activity of PU-H71, a Novel Purine Scaffold HSP90 Inhibitor, is via Inhibition of Both HSP90A and HSP90B1

✍ Scribed by Saad Usmani; Robert Bona; Gabriela Chiosis

Book ID: 119218765
Publisher: Elsevier
Year: 2011
Tongue: English
Weight: 142 KB
Volume: 11
Category: Article
ISSN: 2152-2650
DOI: 10.1016/j.clml.2011.05.024

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## Abstract PU‐H71 is a purine‐scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d~6~‐labeled PU‐H71 for use as an internal standard to accurately quantitate the drug in