Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core.
✍ Scribed by Dirk Menche; Fatih Arikan; Jun Li; Sven Rudolph
- Book ID
- 102002656
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 28 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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📜 SIMILAR VOLUMES
The diastereoselective reduction of a range of acyclic Bhydroxy ketones with triacetoxyborohydride is described. In all cases, the anti 1,3-dial diastereomer is the principal product (eq I).
Page 5939, paragraph 2, sentence 3 should read: The stereochemical information gained from these cases is consistent with a hydroxyl-mediated reduction, a mechanistic postulate first suggested by Saksena.Sa 5. (a) Saksena, A.