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Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core.

✍ Scribed by Dirk Menche; Fatih Arikan; Jun Li; Sven Rudolph


Book ID
102002656
Publisher
John Wiley and Sons
Year
2007
Weight
28 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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📜 SIMILAR VOLUMES


The directed reduction of β-hydroxy keto
✍ David A. Evans; Kevin T. Chapman 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 265 KB

The diastereoselective reduction of a range of acyclic Bhydroxy ketones with triacetoxyborohydride is described. In all cases, the anti 1,3-dial diastereomer is the principal product (eq I).

The directed reduction of β-hydroxy keto
✍ David A. Evans; Kevin T. Chapman 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 27 KB

Page 5939, paragraph 2, sentence 3 should read: The stereochemical information gained from these cases is consistent with a hydroxyl-mediated reduction, a mechanistic postulate first suggested by Saksena.Sa 5. (a) Saksena, A.