Directed immobilization of DNA-binding proteins on a cognate DNA-modified chip surface
✍ Scribed by Eun-Ju Jeong; Yoo Seok Jeong; Kyoungsook Park; So Yeon Yi; Junhyoung Ahn; Sang J. Chung; Moonil Kim; Bong Hyun Chung
- Book ID
- 118245380
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 842 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0168-1656
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📜 SIMILAR VOLUMES
## Abstract The design of a novel polymer‐modified overlayer composed of PPAPE and GPMS on a silicon wafer for immobilization of DNA molecules is described. After hydroxylation of Si(100) surfaces, GPMS molecules were self‐assembled onto these surfaces. PPAPE molecules were then covalently attached
The strategy of molecular evolution by phage display recently has been applied to the study of interactions between protein and DNA. This technology will imminently enable DNA-binding proteins to be made to measure. In the first instance, this will greatly advance our understanding of protein-DNA in