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Direct Synthesis of Protected Arylacetaldehydes by Tetrakis(phosphane)palladium-Catalyzed Arylation of Ethyleneglycol Vinyl Ether.

✍ Scribed by Isabelle Kondolff; Henri Doucet; Maurice Santelli


Publisher
John Wiley and Sons
Year
2006
Weight
17 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Abstract A range of aryl bromides undergo Heck reaction with ethylene glycol vinyl ether, in the presence of [PdCl(C~3~H~5~)]~2~/__cis__,__cis__,__cis__‐1,2,3,4‐tetrakis[(diphenylphosphanyl)methyl]cyclopentane as catalyst, to give regioselectively protected arylacetaldehydes in good yields. The

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Direct Synthesis of Cyclic Ketals of Acetophenones by Palladium-Catalyzed Arylation of Hydroxylalkyl Vinyl Ethers. -It is a simple direct method to prepare ketals of acetophenones. The possibility of selective ketal formation in the presence of an additional carbonyl group is noteworthy.