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Direct Synthesis of 2,5-Disubstituted Oxazoles through an Iodine-Catalyzed Decarboxylative Domino Reaction

✍ Scribed by Xu, Wei; Kloeckner, Ulrich; Nachtsheim, Boris J.


Book ID
120371871
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
895 KB
Volume
78
Category
Article
ISSN
0022-3263

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Synthesis of 2,4- and 2,5-Disubstituted
✍ Carla M. Counceller; Chad C. Eichman; Nicolas Proust; James P. Stambuli 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB 👁 1 views

## Abstract The rapid synthesis of 2,4‐ and 2,5‐disubstituted oxazoles __via__ metal‐catalyzed cross‐coupling reactions is reported. The 4‐ or 5‐position of the corresponding 4‐ or 5‐halogenated 2‐butylthiooxazoles was successfully functionalized __via__ Suzuki–Miyaura, Sonogashira and Stille cross