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Direct repression of the Mcl-1 promoter by E2F1

✍ Scribed by Croxton, Rhonda; Ma, Yihong; Song, Lanxi; Haura, Eric B; Cress, W Douglas


Book ID
110066371
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
437 KB
Volume
21
Category
Article
ISSN
0950-9232

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Regulation of the Pur-alpha promoter by
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Pura is a ubiquitously expressed multifunctional nucleic acid-binding protein that is involved in many cellular processes including transcriptional regulation, the cell cycle, oncogenic transformation, and post-natal brain development. Previously, Pura protein was found to bind to E2F-1, inhibit E2F