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Differences in DNA binding properties between E2F1 and E2F4 specify repression of the Mcl-1 promoter

✍ Scribed by Croxton, Rhonda; Ma, Yihong; Cress, W Douglas


Book ID
110066441
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
253 KB
Volume
21
Category
Article
ISSN
0950-9232

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Previous studies indicated that DNA adducts formed by a carcinogenic diol epoxide, 7r,8t-dihydroxy-9t, 10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normally specific binding sites. It was suggested that a