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Direct Observation of Single Oligomers of the Alzheimer’s Amyloid-β Peptide on Live Cell Membranes

✍ Scribed by Johnson, Robin; Schauerte, Joseph; Wisser, Kathleen; Saluja Igo, Indu; Gafni, Ari; Steel, Duncan

Book ID
119208731
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
37 KB
Volume
100
Category
Article
ISSN
0006-3495

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## Abstract The behavior of the amyloid β‐peptide (Aβ) within a membrane environment is integral to its toxicity and the progression of Alzheimer's disease. Ganglioside GM1 has been shown to enhance the aggregation of Aβ, but the underlying mechanism is unknown. Using atomistic molecular dynamics s