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Effect of Membrane Cholesterol on the Structure of Alzheimer's Amyloid β Peptide in Lipid Bilayers

✍ Scribed by Matos, Jason O.; Bulson, Jeffrey; Tatulian, Suren A.

Book ID
122282039
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
37 KB
Volume
104
Category
Article
ISSN
0006-3495

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## Abstract The behavior of the amyloid β‐peptide (Aβ) within a membrane environment is integral to its toxicity and the progression of Alzheimer's disease. Ganglioside GM1 has been shown to enhance the aggregation of Aβ, but the underlying mechanism is unknown. Using atomistic molecular dynamics s