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Direct linear plotting method for estimation of pharmacokinetic parameters

✍ Scribed by Jeffrey R. Koup

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
223 KB
Volume
70
Category
Article
ISSN
0022-3549

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✦ Synopsis

Recently, a method was described (1) for estimating the parameters of a single-compartment linear pharmacokinetic model following intravenous bolus dose administration. This method is based on the following relationship:

* APPLE I1 plus, DOS 3.2.1.

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## Abstract An alternate development of the quasilinearization method for parameter estimation is presented to enable a more efficient implementation of the algorithm. Similarity of this algorithm to Gauss‐Newton method is shown and attention is given to systems having a nonlinear relationship betw