Simplification of quasilinearization method for parameter estimation
β Scribed by Nicolas Kalogerakis; Rein Luus
- Publisher
- American Institute of Chemical Engineers
- Year
- 1983
- Tongue
- English
- Weight
- 742 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0001-1541
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
An alternate development of the quasilinearization method for parameter estimation is presented to enable a more efficient implementation of the algorithm. Similarity of this algorithm to GaussβNewton method is shown and attention is given to systems having a nonlinear relationship between the observed and state variables. To overcome the problem of a small region of convergence, the use of direct search optimization is proposed for the first few iterations, followed by the simplified quasilinearization algorithm.
π SIMILAR VOLUMES
Recently, a method was described (1) for estimating the parameters of a single-compartment linear pharmacokinetic model following intravenous bolus dose administration. This method is based on the following relationship: \* APPLE I1 plus, DOS 3.2.1.