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Direct determination of non-steroidal anti-inflammatory drugs by column-switching LC–MS

✍ Scribed by Koichi Suenami; Lee Wah Lim; Toyohide Takeuchi; Yasuhide Sasajima; Kiyohito Sato; Yuji Takekoshi; Susumu Kanno

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
484 KB
Volume
29
Category
Article
ISSN
1615-9306

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✦ Synopsis

A method for determination of 16 non-steroidal anti-inflammatory drugs (NSAIDs) in human plasma samples without time-consuming sample pre-treatments was developed. The system consisted of two pumps for mobile phase delivery, a six-port switching valve, a pre-column (Oasis HLB Cartridge Column), and a reversed phase analytical column (COSMOSIL 3C18-MS-II). The analytes were trapped on the precolumn and subsequently separated on the analytical column. The present method allowed on-line sample clean-up and enrichment, leading to improved sensitivity without any tedious sample preparation. The recoveries of NSAIDs from human plasma by column-switching were greater than 72.6%. The total analysis time for a single analytical run was approximately 11 min. The detection limits of NSAIDs were 0.0025 to 0.2 microg/mL using the selected ion monitoring mode.

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