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The determination of non-steroidal anti-inflammatory drugs by GC—MS—MS in equine urine

✍ Scribed by E.G. de Jong; J. Kiffers; R.A.A. Maes

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
401 KB
Volume
7
Category
Article
ISSN
0731-7085

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✦ Synopsis

Results are given for a more sensitive screening procedure for non-steroidal anti-inflammatory drugs using GC-MS-MS. By monitoring a selected characteristic reaction for each drug very low detection limits are reached even in a difficult biological matrix such as equine urine. Detection down to 5 ng ml-1 for ibuprofen, ibufenac, alclofenac, fenoprofen, ketoprofen, naproxen and diclofenac is possible in contrast to the 0.5 microgram ml-1 limit for normal GC-MS detection. Examples are given of real positive cases for diclofenac and ibuprofen.

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