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Direct Asymmetric α-Fluorination of Aldehydes.

✍ Scribed by Derek D. Steiner; Nobuyuki Mase; Carlos F. III Barbas

Publisher
John Wiley and Sons
Year
2005
Weight
28 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Halogenation O 0235 Direct Organocatalytic α-Fluorination of Aldehydes and Ketones. -A first protocol employs proline as the catalyst and Selectfluor as the electrophilic source of fluorine. The asymmetric induction is further investigated with various proline analogues (VII) and found to be ra