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Direct Organocatalytic α-Fluorination of Aldehydes and Ketones.

✍ Scribed by Dieter Enders; Matthias R. M. Huettl

Publisher
John Wiley and Sons
Year
2005
Weight
24 KB
Volume
36
Category
Article
ISSN
0931-7597

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✦ Synopsis

Halogenation O 0235

Direct Organocatalytic α-Fluorination of Aldehydes and Ketones. -A first protocol employs proline as the catalyst and Selectfluor as the electrophilic source of fluorine. The asymmetric induction is further investigated with various proline analogues (VII) and found to be rather low. The best result is obtained with derivative (VIIc). -(ENDERS*, D.;

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✍ Derek D. Steiner; Nobuyuki Mase; Carlos F. Barbas III 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB 👁 1 views

Organic molecules containing fluorine have attracted much attention because they show distinctive characteristics in comparison with their parent compounds owing to the unique CÀF bond. [1] Substitution of hydrogen by fluorine is often considered isosteric and the high C À F bond strength generally