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Direct asymmetric aldol reactions catalyzed by l-proline-2,4,6-trinitroanilide

✍ Scribed by Kosuke Sato; Masami Kuriyama; Rumiko Shimazawa; Tsumoru Morimoto; Kiyomi Kakiuchi; Ryuichi Shirai

Book ID: 104095096
Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 260 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.02.066

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✦ Synopsis

Direct aldol reactions of several aromatic aldehydes with ketones using L-proline-2,4,6-trinitroanilide catalyst 2d were conducted. Under optimized conditions, high enantioselectivity (99% ee), regioselectivity (up to 95:5), and diastereoselectivity (up to 98:2) were achieved.

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