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ChemInform Abstract: Direct Asymmetric Aldol Reactions Catalyzed by L-Proline/PEG/SiO2 Composite Catalyst.

โœ Scribed by Na Xu; Dong Xue; Ling Liu; Zhao-Tie Liu; Jian Lu; Zhong-Wen Liu


Book ID
115552411
Publisher
John Wiley and Sons
Year
2012
Weight
24 KB
Volume
43
Category
Article
ISSN
0931-7597

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Direct asymmetric aldol reactions cataly
โœ Kosuke Sato; Masami Kuriyama; Rumiko Shimazawa; Tsumoru Morimoto; Kiyomi Kakiuch ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 260 KB

Direct aldol reactions of several aromatic aldehydes with ketones using L-proline-2,4,6-trinitroanilide catalyst 2d were conducted. Under optimized conditions, high enantioselectivity (99% ee), regioselectivity (up to 95:5), and diastereoselectivity (up to 98:2) were achieved.