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Direct Asymmetric a nti -Mannich-Type Reactions Catalyzed by a Designed Amino Acid

โœ Scribed by Mitsumori, Susumu; Zhang, Haile; Ha-Yeon Cheong, Paul; Houk, K. N.; Tanaka, Fujie; Barbas, Carlos F.

Book ID
120022621
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
52 KB
Volume
128
Category
Article
ISSN
0002-7863

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Acyclic ฮฒ-Amino Acid Catalyzed Asymmetri
Acyclic ฮฒ-Amino Acid Catalyzed Asymmetric anti-Selective Mannich-Type Reactions.
โœ Pawel Dziedzic; Armando Cordova ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons โš– 27 KB ๐Ÿ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

anti-Selective SMP-catalyzed direct asym
anti-Selective SMP-catalyzed direct asymmetric Mannich-type reactions: synthesis of functionalized amino acid derivatives
โœ Armando Cรณrdova; Carlos F Barbas III ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 95 KB

The first (S)-2-methoxymethylpyrrolidine (SMP)-catalyzed direct asymmetric Mannich-type reactions of unmodified aldehydes with N-PMP-protected a-imino ethyl glyoxylate are described. The reaction proceeded in a highly anti-selective manner (dr up to 19:1) with enantioselectivities between 74 and 92%