Direct and catalytic synthesis of quinoxaline derivatives from epoxides and ene-1,2-diamines
✍ Scribed by Sylvain Antoniotti; Elisabet Duñach
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 300 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
We describe here a new synthesis of quinoxaline derivatives by a Bi-catalyzed oxidative coupling of epoxides and ene-1,2-diamines.
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## Abstract Alkyl 3‐(alkylamino)‐5,6‐dicyanopyrazine‐2‐carboxylates and alkyl 3‐(alkylamino)quinoxaline‐2‐carboxylates were obtained in good yields by treatment of __Nef__‐isocyanide adducts with 1,2‐diamines in MeCN.
A complete synthesis of enantiopure trans-cyclopentane-1,2-diamine and trans-cyclobutane-1,2-diamine is described. These diamines have been used as components of novel chiral salen ligands whose chromium and manganese complexes were then evaluated as oxygen transfer agents in the asymmetric epoxidat