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Dipole Interaction-Controlled Stereoselectivity in Aldol Reaction of α-CF 3 Enolate with Fluoral

✍ Scribed by Itoh, Yoshimitsu; Yamanaka, Masahiro; Mikami, Koichi


Book ID
125816131
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
126 KB
Volume
5
Category
Article
ISSN
1523-7060

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Boron enolates bearing menthone-derived chiral ligands are capable of fair to excellent diastereocontrol in their reactions with chiral aldehydes. Thioester-derived (better than ketone derived) enolates are able to control aldol stereochemistry irrespective of the aldehyde preferences. With thioacet