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ChemInform Abstract: Reagent Control in the Aldol Addition Reaction of Chiral Boron Enolates with Chiral α-Amino Aldehydes. Total Synthesis of (3S, 4S)-Statine (VIII).

✍ Scribed by C. GENNARI; G. PAIN; D. MORESCA


Book ID
112028165
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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Reagent control in the aldol addition re
✍ Cesare Gennari; Daniela Moresca; Anna Vulpetti; Gilles Pain 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 930 KB

Boron enolates bearing menthone-derived chiral ligands are capable of fair to excellent diastereocontrol in their reactions with chiral aldehydes. Thioester-derived (better than ketone derived) enolates are able to control aldol stereochemistry irrespective of the aldehyde preferences. With thioacet